Say you want to watch your team play every other team in the league...
Under the current season structure, each NBA, NHL, and MLB team play in every stadium every season, making an ultimate road trip where one travel to see their team play against every away opponent once possible. This trip can be optimized according to a variety of criteria, including total length in days and total distance driven etc.
Similar road trips can be constructed for MLS and NFL (with the caveat of not playing all other teams in the league). Although these trips have less potential for optimization as both leagues play roughly one day a week.
Given a set of events
The traditional TSP in this formulation uses a decision function